H1 FY25 FINANCIAL RESULT HIGHLITS
Home Blog Page 8516

Drug combo shuts down tumour growth in aggressive Lung Cancer

0
drug combo-indianbureaucracy
drug combo-indianbureaucracy

Acombination treatment consisting of the rheumatoid arthritis drug auranofin and an experimental targeted agent may shut down one of the most common and lethal forms of lung cancer, says a study.

The combination therapy worked in a laboratory study to stop lung adenocarcinoma associated with mutation of the KRAS gene.

“If our approach works in KRAS-mediated lung adenocarcinoma, it may work in other KRAS-mediated cancers, such as pancreatic and colon cancers, as well as other cancer types,” said the study’s senior author Alan Fields, cancer biologist at Mayo Clinic in Florida, US.

The study was published in the journal Cancer Cell.

 The researchers found that the combination therapy shuts down a major signaling pathway, or set of molecular mechanisms, that stimulates the growth of cancer stem cells in KRAS-mediated lung adenocarcinoma.
“Cancer stem cells are the really bad actors in many cancers,” Fields explained.
“Cancer stem cells initiate cancer development, drive its growth and metastasis, and also develop resistance to treatments,” Fields noted.
This research indicates auranofin might be useful in treating many different cancer types,” Fields said.
Based on this and other preclinical research, the team is conducting early-phase clinical trials to test the effectiveness of auranofin alone and in targeted combinations in patients with KRAS-mediated lung adenocarcinoma, ovarian cancer, and another common lung cancer called lung squamous cell carcinoma.

Northern Rail commissions Ghaziabad – Meerut City – Saharanpur electrification

0
Railway Board
indian_Railways

Meerut City-Saharanpur section (113 route kilometre) of Northern Railway has been commissioned on electric traction on 12.3.2016, after inspection and authorisation of Commissioner of Railway Safety, Northern Circle. Earlier Ghaziabad-Meerut City section was commissioned on electric traction on 3.12.2015.

In this way, now electrification of entire Ghaziabad – Meerut- Saharanpur section of 161 route kilometre has been completed. This entire project at an estimated cost of Rs. 275 Crore has been executed by Central Organisation for Railway Electrification (CORE). Electric trains now can run seamlessly from Delhi/Ghaziabad/Khurja towards Haridwar, Ambala, Jammu, Amritsar etc. with reduction in journey time between 30 to 60 minutes. Sectional traffic throughput will also increase with electrification leading to higher capacity.

IndianBureaucracy.com wishes the very best.

How more R&D funding can hasten Green Revolution

0
science indianbureaucracy
science indianbureaucracy

Summary:A uniquely detailed model of the dynamics of innovation in the energy industry has been explained in a new article. In so doing, researchers indicate how supporting clean energy R&D, not just a carbon tax, might be the best way to help clean energy technologies compete with traditional forms of energy.

“Most people know we are frying the planet,” says MIT economist Daron Acemoglu, referring to the effects of climate change. After all, 2015 was the hottest year on record, portending drastic long-term problems involving agriculture, rising sea levels, drought, and much more.

“What is probably less clear is how to resolve that,” Acemoglu adds.

On one level, we know the answer: Replace carbon-emitting fossil fuels with clean energy, including solar and wind power. To do this, many economists recommend a carbon tax. A smaller number of experts also endorse more government funding for research and development (R&D) in clean energy. In theory, both measures should make clean energy more economically competitive with oil, gas, and coal.

But to what extent would those policies influence the transition from dirty energy to clean energy? In a newly published paper, Acemoglu and three colleagues present a uniquely detailed model of the dynamics of innovation in the energy industry. In so doing, they indicate how supporting clean energy R&D, not just a carbon tax, might be the best way to help clean energy technologies compete with traditional forms of energy.

“We propose that you use the carbon tax in moderation and use research subsidies for clean technology in order to make that transition faster,” says Acemoglu, the Elizabeth and James Killian Professor of Economics at MIT. And on the R&D front, he adds, “The optimal policy is front-loaded intervention right away.”

Indeed, the model indicates that an ideal policy would feature both a high initial level of R&D subsidies, which would drop to nearly zero after 50 years, and a carbon tax that increases over a roughly 130-year period before dropping off. A crucial mechanism at work is that the high R&D subsidy allows for a quicker transition to clean energy while not slowing down economic growth, as a carbon tax alone would.

“Clean technologies allow you to bypass the growth-retarding implications of a carbon tax,” Acemoglu explains.

And given that the effects of climate change will have heavy social costs, the scholars also estimate the costs of not implementing this kind of two-front policy. Delaying what they believe is the optimal policy by 50 years, the researchers estimate, would have a social welfare cost equivalent to a perpetual 1.7 percent drop in annual consumption, from today forward. And relying only on a carbon tax, with no R&D subsidies in the mix, would be equivalent to a 1.9 percent annual drop in consumption.

The federal budget for the 2016 fiscal year included about $6.4 billion in clean energy research funding; the White House has proposed doubling that by the 2021 fiscal year.

The paper detailing the research, “Transition to Clean Technology,” is published in the latest issue of the Journal of Political Economy. In addition to Acemoglu, the co-authors are Ufuk Akcigit of the University of Pennsylvania, Douglas Hanley of the University of Pittsburgh, and William Kerr of Harvard University.

Mind the gap

The research uses detailed historical data from 1976-2009 to build a model of the competition between clean and dirty (or carbon-emitting) forms of energy, and analyzes what that competition would look like under varying sets of conditions, such as those driven by policy changes.

The data in the model include information about R&D expenditures, patents, sales, employment, and more, extracted from the U.S. Census Bureau, the National Science Foundation, and the National Bureau of Economic Research. The researchers used data covering 1,576 firms in the energy sector, which make up 19 percent of U.S. R&D and generate 70 percent of energy patents.

In the model, energy technologies move in a series of advances — think rungs on a ladder — while competing against each other. Given essentially the same costs, equivalent clean and dirty technologies competing against each other should fare equally well, more or less, in terms of things like patenting, which can be used to measure technological advances. The historical data helps the researchers quantify the relationship between funding and innovation, among other things.

However, the playing field is currently not equal in energy technology. Among other matters, the study shows that across a wide swath of industries, fossil-fuel firms have a higher cumulative stock of patents in 87 percent of the specific technology categories the study details, compared with clean-energy firms.

Moreover, in those cases, the gap between the leading-edge technologies and the competitors trying to catch up is on aggregate twice as great for the fossil-fuel firms than the clean-technology firms; that is, the dirty energy companies are generally farther ahead of the other firms in their fields.

The takeoff to self-sustaining innovation

That’s why R&D subsidies, and not just a carbon tax, matter so much. As the data and model reveal, a technological edge can sustain itself, since it produces revenue that can lead to further improvements in that technology. Meanwhile, R&D investment in competing technologies will lag if a near-term payoff is not available.

Thus, as the scholars write in the paper, “if clean research can be successfully maintained for a while, it gradually becomes self-sustaining as the range of clean technologies that can compete with dirty ones expands as a result of a series of incremental innovations.”

Or, as Acemoglu puts it: “The problem of making a transition to new technology is one of learning by doing at some level. The longer you delay, the harder it is to do it, because the farther ahead conventional fossil-fuel technologies become relative to green energy — solar, wind, geothermal.”

By adjusting the inputs of the model — such as the amount of R&D funding and the level of a carbon tax — the researchers were able to assess what changes in those levels make sense over time.

Acemoglu also notes that the R&D in their model is not directed toward geoengineering research, that is, attempts to capture or limit existing carbon in the atmosphere; rather, the study is focused on the production of clean energy in the first place.

And despite the long time frames at work, he emphasizes that we have little time to squander when it comes to climate change.

“The problem is severe enough that you want to take action today,” Acemoglu concludes.

Source:Massachusetts Institute of Technology(science)

Yoga may improve quality of life for Abnormal Heart Rhythm patients

0
yoga-indianbureaucracy
yoga-indianbureaucracy

Yoga may improve quality of life in patients suffering from abnormal heart rhythm because it gives them a method to gain some self control over their symptoms instead of feeling helpless, says a new study.

The researchers examined the effects of yoga on patients with paroxysmal atrial fibrillation (AF) in which faulty electrical signals and rapid heart rate begin suddenly and then stop on their own.

“Many patients with paroxysmal atrial fibrillation (AF) can’t live their lives as they want to — they refuse dinners with friends, concerts and travelling – because they are afraid of an AF episode occurring,” said one of the researchers Maria Wahlstrom from Sophiahemmet University in Sweden.

“AF episodes are accompanied by chest pain, dyspnoea and dizziness,” added Wahlstrom in the study published in the European journal of cardiovascular nursing.

These symptoms are unpleasant and patients feel anxious, worried and stressed that an AF episode would occur.

AF is the most common cardiac rhythm disorder and has no cure, the researches pointed out.

Patients with paroxysmal AF experience episodes of AF usually lasting less than 48 hours and stop by themselves, although in some patients they can last up to seven days.

The team included 80 patients with paroxysmal AF who were randomised to yoga or a control group that did not do yoga.

Yoga was performed for one hour, once a week, for 12 weeks in the hospital with an experienced instructor, which included light movements, deep breathing and meditation.

After 12 weeks, the yoga group had higher “SF-36” mental health scores, lower heart rate and lower systolic and diastolic blood pressure than the control group.

“We found that patients who did yoga had a better quality of life, lower heart rate and lower blood pressure than patients who did not do yoga. The breathing and movement may have beneficial effects on blood pressure,” Wahlstrom stated.

“Patients in the yoga group said it felt good to let go of their thoughts and just be inside themselves for awhile,” Wahlstrom noted.

REC CSR Initiative: Modular OT inaugurated at SVNITR, Cuttack

0
REC Transmission Projects Company-indianbureaucracy
REC Transmission Projects Company-indianbureaucracy

Rural Electrification Corporation Ltd. (REC) has provided financial assistance to Swami Vivekananda National Institute of Rehabilitation Training and Research (SVNIRTAR) in setting up of Modular Operation Theater and procurement of various Medical Equipment to improve medical services for persons with disabilities to the tune of Rs 2.96 Crore under REC’s CSR programme.

The Modular O/T and GAIT Laboratory was inaugurated on 13th March,2016 by Shri Thaawar Chand Gehlot, Union Minister(SJ&E) in the presence of Shri K.P.Gurjar, Minister of State(SJ&E) , Shri Rajeev Sharma, CMD, REC and senior members of the institute.

About REC: Rural Electrification Corporation Limited (REC), a NAVRATNA Central Public Sector Enterprise under Ministry of Power, was incorporated on July 25, 1969 under the Companies Act 1956. REC a listed Public Sector Enterprise Government of India with a net worth of Rs. 24,857.03 crore as on 31.03.15. Its main objective is to finance and promote rural electrification projects all over the country. It provides financial assistance to State Electricity Boards, State Government Departments and Rural Electric Cooperatives for rural electrification projects as are sponsored by them.

REC provides loan assistance to SEBs/State Power Utilities for investments in rural electrification schemes through its Corporate Office located at New Delhi and 20 field units, which are located in most of the States.

More: REC India

Related Articles:

https://www.indianbureaucracy.com/rural-electrification-corporation-sets-aside-10-crores-for-csr/#sthash.7FabFV0X.dpbs

https://www.indianbureaucracy.com/rec-initiates-pilot-project-in-bihar-with-help-from-iit-madras/#sthash.SFUUyK4y.dpbs

https://www.indianbureaucracy.com/rec-assistance-for-visually-impaired-students-in-jnu/

Airports Authority of India participates in India Aviation 2016, Hyderabad

0
india-aviation-2016_indianbureaucracy_AAI_Ficci
india-aviation-2016_indianbureaucracy_AAI_Ficci

Airports Authority of India is participating in the India Aviation, 2016 being held in India this year at very large scale under the patronage of Ministry of Civil Aviation which is jointly organized by AAI and FICCI.  The event is from 16th to 20th March, 2016 at Begumpet Airport of AAI in which corporate companies from world over are taking part to showcase the power of Civil Aviation globally.

AAI stall was inaugurated by Hon’ble Minister of Civil Aviation, Shri Ashok Gajapathi Raju Pusapati in the presence of Shri Anil Shrivastava, Joint Secretary, Ministry of Civil Aviation and Shri R K Srivastava, Chairman, AAI & other officials.

This year AAI has placed a very unique stall in India Aviation Exhibition attracting many visitors as it reflects the feel of terminal building, Air traffic Control Tower, Runway and Aircraft.  In addition to this, it also depicts details of achievements of AAI, Infrastructure development cargo activities and other new technologies adopted by AAI for the smooth flow of traffic from Indian Airports.

IndianBureaucracy.com wishes the very best.

Boeing & Nok Air celebrate 737 Delivery

0
boeing-indianbureaucracy
boeing-indianbureaucracy

Boeing delivered Nok Air’s 21st Next-Generation 737-800 during a ceremony at the Seattle Delivery Center. The celebration marked the third direct-purchased 737-800 to be delivered to Nok Air.

“We are extremely pleased to welcome another new 737-800 to our growing all-Boeing fleet,” said Patee Sarasin, CEO of Nok Air. “The 737 provides us with the efficiency and reliability that is needed to succeed in today’s competitive environment. This airplane will continue to form the backbone of our fleet and we look forward to providing our customers with the best flying experience onboard our new airplanes.”

Boeing Flight Services pilots flew Nok Air’s newest 737 to Bangkok and kicked off a world-class flight training program with the airline to help strengthen the capabilities of Nok Air’s rapidly expanding flight crew.

“Boeing’s high quality flight training program will continue to help us grow our flight crew as we look to meet the ever raising demands with the most outstanding team members,” said Sarasin. “Our passengers deserve to be flown by the best pilots in the world and we are working diligently to see that our quality is excellent as our operations continue to expand.”

Boeing Flight Services provides integrated offerings to drive optimized performance, efficiency and safety through advanced flight, maintenance and cabin safety training as well as simulator support and services through a global network of campuses on six continents.

According to the 2015 Boeing Pilot & Technician Outlook, an industry forecast of aviation personnel demand closely tied to projections for new airplane deliveries around the globe, 226,000 new commercial airline pilots and 238,000 new technicians will be needed in the Asia-Pacific region through 2034.

“There is a growing demand for well-trained pilots in Thailand, and we look forward to working with Nok Air as they continue to expand their operations in the busy Asia-Pacific region” said Steve Taylor, Chief Pilot, Boeing Flight Services.

Asia leads the world for demand of new commercial airplane deliveries over the next 20 years. By 2034, 14,330 new airplanes worth $2.2 trillion will be needed in the region, according to Boeing’s 2015 Current Market Outlook.

By providing customers the support and services they require, such as pilot training, Boeing provides customers a competitive advantage by solving real operational problems, enabling better decisions, maximizing efficiency and improving environmental performance.

IndianBureaucracy.com wishes the very best.

New blood test could Detect Multiple Diseases

0
blood
blood -indianbureaucracy

Scientists have developed a new blood test that may detect multiple diseases, including diabetes, cancer, traumatic injury and neurodegeneration, in a highly sensitive and specific manner.

The novel method, developed in a series of experiments involving 320 patients and controls, infers cell death in specific tissue from the methylation patterns of circulating DNA that is released by dying cells.

Cell death is a central feature of human biology in health and disease, according to researchers led by Ruth Shemer and Yuval Dor from The Hebrew University of Jerusalem, and Benjamin Glaser from Hadassah Medical Centre.

It can signify the early stages of pathology (Eg: a developing tumour or the beginning of an autoimmune or neurodegenerative disease), mark disease progression, reflect the success of therapy (EG:anti cancer drugs), identify unintended toxic effects of treatment and more.

However to date, it is not possible to measure cell death in specific human tissues non-invasively.

The new blood test detects cell death in specific tissues by combining two important biological principles. First, dying cells release fragmented DNA to the circulation, where it travels for a short time.

The second principle is that the DNA of each cell type carries a unique chemical modification called methylation.

Methylation patterns of DNA account for the identity of cells (the genes that they express), are similar among different cells of the same type and among individuals, and are stable in healthy and disease conditions.

 For example, the DNA methylation pattern of pancreatic cells differs from the pattern of all other cell types in the body. The researchers have identified multiple DNA sequences that are methylated in a tissue-specific manner (for example, unmethylated in DNA of neurons and methylated elsewhere), and can serve as biomarkers for the detection of DNA derived from each tissue.
They then developed a method to detect these methylated patterns in DNA circulating in blood, and demonstrated its utility for identifying the origins of circulating DNA in different human pathologies, as an indication of cell death in specific tissues.
They were able to detect evidence for pancreatic beta-cell death in the blood of patients with new-onset type 1 diabetes, oligodendrocyte death in patients with relapsing multiple sclerosis, brain cell death in patients after traumatic or ischemic brain damage, and exocrine pancreas cell death in patients with pancreatic cancer or pancreatitis.
“Our work demonstrates that the tissue origins of circulating DNA can be measured in humans. This represents a new method for sensitive detection of cell death in specific tissues, and an exciting approach for diagnostic medicine,” said Shemer.

Brain Maps highlight Autism Disorders

0
science indianbureaucracy
science indianbureaucracy

Summary:Brain maps of people with autism spectrum disorders (ASD) show different levels of connectivity between parts of the brain compared with typical individuals, scientists report.

Brain maps of people with autism spectrum disorders (ASD) show different levels of connectivity between parts of the brain compared with typical individuals.

Autism spectrum disorder is a group of neurological dysfunctions ranging from hyperactivity to Asperger’s syndrome, resulting in challenges in thinking, talking, recognizing and expressing emotion, and social interactions. Researchers at University of Malaysia Sarawak compared the brainwave patterns of ten individuals with ASD to those of ten typical individuals to try to pinpoint what anomalies might be associated with particular disorders.

The team used a quantitative electroencephalogram (QEEG), which measures electrical activity through 19 electrodes resting on the head during specific tasks. It allows them to see brainwaves that move at different frequencies, creating a brain map showing more or less activity in different regions of the brain.

Overall, individuals with ASD have fewer beta waves throughout the brain than normal, indicating under-connectivity throughout the brain. Decreased beta waves are usually associated with attention problems, learning disabilities and brain injuries.

The brain maps further revealed ASD individuals had both excessive slow and fast waves in the frontal lobe. This might suggest faulty connections between the front and back regions of the brain.

ASD individuals also had reduced alpha waves in brain regions associated with senses and gross motor movement, which might explain why they could not mimic instructed tasks.

The observations are consistent with other studies using different brain imaging tools, like functional magnetic resonance imaging. The researchers note that by observing specific anomalies with QEEG, clinicians can develop individualized neurofeedback training plans for ASD patients. Neurofeedback training involves measuring an individual’s brainwaves and producing auditory and/or visual signals as feedback to the brain to teach it to regulate its own functions. The researchers found that neurofeedback training based on a QEEG-guided protocol was more effective than neurofeedback based on symptoms.

Source:ResearchSEA(science)

Govt considering Structured Regulatory Framework for AYUSH Drugs

0
AYUSH_Logo-indianbureaucracy
AYUSH_Logo-indianbureaucracy

Minister of State for AYUSH (Independent Charge) and Health & Family Welfare, Shri Shripad Yesso Naik has informed that. Government has considered setting up a structured central regulatory framework for AYUSH drugs. In this regard, the current proposal is to develop a vertical structure for AYUSH in the Central Drugs Standard Control Organization (CDSCO). Accordingly, amendments required in the Drugs & Cosmetics Act, 1940 pertaining to regulation of Ayurvedic, Siddha, Unani, Sowa-rigpa and Homoeopathy drugs have been conceptualized and conveyed to the Department of Health & Family Welfare under whose jurisdiction the proposal of amending Drugs & Cosmetics Act, 1940 and strengthening of CDSCO are being processed. Ministry of AYUSH has notified creation of 12 posts of Deputy Drugs Controllers, Assistant Drugs Controllers and Inspectors of Ayurvedic, Siddha, Unani and Homoeopathy and the matter of vertical structure for AYUSH drugs in CDSCO has been followed up regularly with the Department of Health & Family Welfare. Certain changes relating to AYUSH have been included in draft Bill for amending the Drugs & Cosmetics Act 1940 and the Bill has been considered by a Group of Ministers.

AYUSH drugs are regulated in the country in accordance with the provisions of Drugs & Cosmetics Act, 1940 and Rules thereunder. Good Manufacturing Practices and Standards of AYUSH drugs as prescribed in the Drugs & Cosmetics Rules and Pharmacopoeias are mandatory for the manufacturers to follow. Voluntary certification scheme for Ayurvedic, Siddha and Unani as per WHO guidelines is also in place, under which eight manufacturers have obtained WHO Certification of Pharmaceutical Products for their AYUSH products. Regulatory provisions are amended time to time in consultation with the Ayurvedic, Siddha and Unani Drugs Technical Advisory Board and standards of drugs are developed by the Pharmacopoeia Commission and respective Pharmacopoeia Committees.

The Government has set up Pharmacopoeia Commission of Indian Medicine & Homoeopathy and Pharmacopoeia Committees to develop quality standards and Standard Operating Procedures for the manufacturing of Ayurvedic, Siddha, Unani and Homoeopathic drugs. Two central Pharmacopoieal Laboratories of Indian Medicine and Homoeopathy are set up as appellate laboratories and forty one laboratories are approved under the provisions of Drugs & Cosmetics Rules, 1945 for carrying out analysis of drugs and raw materials. Central Government has supported twenty seven State Drugs Testing Laboratories and 46 Pharmacies to improve quality production and testing facilities for AYUSH drugs. Through National AYUSH Mission, financial support is provided to the States for strengthening the infrastructural and functional capacity of the Drugs Testing Laboratories, Pharmacies, and Enforcement Framework and for testing of drugs and quality control activities. Quality Council of India with support from Ministry of AYUSH has implemented a scheme of quality certification of Ayurvedic, Siddha and Unani drugs with brand of AYUSH Standard and AYUSH Premium marks.

Yogesh Deshmukh appointed Joint Director- Security, Parliament Housing

0
Yogesh Deshmukh IPS -indianbureaucracy
Yogesh Deshmukh IPS -indianbureaucracy

Shri Yogesh Deshmukh IPS (Madhya Pradesh 1995) presently posted as Director Vigilance (Police), Railway Board, New Delhi, has been appointed Joint Director (Security) Parliament Housing, New Delhi.

IndianBureaucracy.com wishes Shri Deshmukh the very best.

A S Bhatia IAS is CEO- Investor Edu & Protection Fund Authority as addl charge

0
Amardeep Singh Bhatia
Amardeep Singh Bhatia

Shri Amardeep Singh Bhatia IAS (Nagaland 1993) presently posted as , Joint Secretary Corporate Affairs, has been given additional charge of CEO, Investor Education and Protection Fund Authority for the period up to 14th October 2016.

IndianBureaucracy.com wishes Shri Bhatia the very best .